Small intestine & ampulla
Malabsorption
Tufting enteropathy
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 August 2012
Last staff update: 18 November 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Tufting enteropathy small bowel
Table of Contents
Definition / general | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Electron microscopy description | Electron microscopy imagesCite this page: Gulwani H. Tufting enteropathy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/smallboweltufting.html. Accessed March 28th, 2023.
Definition / general
- Intractable diarrhea syndrome, sometimes familial, beginning in neonates
- Also called intestinal epithelial dysplasia (Orphanet J Rare Dis 2007;2:20)
- Due to epithelial cell adhesion molecule gene (EpCAM) (Gastroenterology 2008;135:429, Gut Liver 2010;4:407)
Treatment
- Total parental nutrition
Microscopic (histologic) description
- Variable villus abnormality, epithelial crowding, disorganization and focal tufting
- No epithelial lymphocytosis
Microscopic (histologic) images
Images hosted on other servers:
Various images
Electron microscopy description
- Basement membrane abnormalities; increase in desmosome length and number; decreased number of microvilli of surface enterocytes with structural disorganization
Electron microscopy images
Images hosted on other servers:
Various images
