Soft tissue

Adipose tissue tumors

Other benign lesions


Topic Completed: 1 June 2012

Minor changes: 31 March 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Lipomatosis [title] tissue

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Cite this page: Singh C. Lipomatosis. website. Accessed October 18th, 2021.
Definition / general
  • Diffuse overgrowth of mature adipose tissue
  • Rare disorder of children under 2 years or adults
  • Associated with obesity, Cushing’s disease, steroid therapy, protease inhibitors for HIV
  • Familial multiple lipomatosis: rare, usually autosomal dominant; multiple lipomas of trunk and extremities with relative sparing of the head and shoulders; due to translocation involving high-mobility-group protein isoform I-C on chromosome 12 and the lipoma preferred partner gene on chromosome 3 (An Bras Dermatol 2012;87:324)
  • Limb (may cause massive enlargement) or trunk
Case reports
  • Palliative surgical removal of excess fat
  • May recur
  • May lead to amputation of extremity due to distortion or loss of function
Gross description
  • Poorly circumscribed aggregates of normal appearing fat in subcutaneous and skeletal muscle (but not confined to muscle)
  • Does not affect nerves
Microscopic (histologic) description
  • Sheets and lobules of white adipose tissue that may infiltrate skeletal muscle
  • May involve bone
Positive stains
Additional references
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