Soft tissue

Adipose tissue tumors

Other benign lesions

Lipomatosis of nerve



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Last staff update: 13 September 2023

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PubMed Search: Lipomatosis nerve

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Cite this page: Singh C. Lipomatosis of nerve. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissueadiposelipomatosisnerve.html. Accessed February 26th, 2024.
Definition / general
  • Infiltration of epineurium of a major nerve by adipose and fibrous tissue
Terminology
  • Also called fibrolipoma of nerve, fibrolipomatous hamartoma of nerve, macrodystrophia lipomatosa
Epidemiology
  • May be noted at birth
  • Almost always age 30 years or less
  • Associated with macrodactyly (abnormal enlargement of digits) innervated by affected nerve in 30 - 67%
Sites
  • 85% have involvement of median nerve and its digital branches in hand, wrist and forearm (Histopathology 1994;24:391)
  • Also ulnar nerve
Radiology description
  • T1 weighted images on MR imaging reveal a fatty mass that is evenly distributed between nerve bundles and is seen running along individual nerves
  • Often described as having a "coaxial cable-like" appearance on axial scans (Acta Radiol 2003;44:326)
Radiology images

Contributed by Mark R. Wick, M.D.

Xray



Images hosted on other servers:

Lipomatosis of
the median nerve
in a patient with
macrodactyly

Lipomatosis of
the median nerve
in a patient without
macrodactyly

Case reports
Treatment
  • Benign but often no effective treatment as resection causes sensory and motor deficits (J Neurosurg 1998;89:683)
  • Carpal tunnel release may relieve symptoms of median nerve involvement
  • Amputation if severe deformity
  • May recur in 33 - 60% if incomplete resection
Clinical images

Images hosted on other servers:

Median nerve

Gross description
  • Fusiform enlargement of nerve by yellow adipose tissue, confined within epineurium
Gross images

Images hosted on other servers:

Lipomatosis of
the median nerve
in a patient with
macrodactyly

Lipomatosis of
the median nerve
in a patient without
macrodactyly

Microscopic (histologic) description
  • Infiltration of epineurium and perineurium by adipose and fibrous tissue (collagen), causing enlargement of nerve
  • Concentric perineurial fibrous tissue and pseudo-onion bulb formation
  • Occasionally metaplastic bone
Microscopic (histologic) images

Contributed by Charanjeet Singh, M.D., Mark R. Wick, M.D., Saroona Haroon, M.D. and Geoffrey A. Talmon, M.D. (Case #158)

Lipoma of nerve

Various images

Various images


Lipomatosis of nerve



Images hosted on other servers:

Lipomatosis of
the median nerve
in a patient without
macrodactyly

Angiolipoma in the
subcutaneous thigh
of a 21 year old man

Differential diagnosis
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