Soft tissue

Extraskeletal bone tumors

Aneurysmal bone cyst

Topic Completed: 1 November 2012

Minor changes: 20 November 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Aneurysmal bone cyst [title]

Vijay Shankar, M.D.
Page views in 2020: 1,216
Page views in 2021 to date: 862
Cite this page: Shankar V. Aneurysmal bone cyst. website. Accessed October 16th, 2021.
Definition / general
  • Features identical to intraosseous aneurysmal bone cyst
  • Rapidly growing, benign mass of deep soft tissue of upper extremities, thigh or groin, without involvement of adjacent bones
  • Mean age 28 years, range 8 - 37 years
  • May recur locally if incompletely excised
Case reports
Gross description
  • Median 4 cm, range 2.5 - 9 cm, surrounded by thin rim of bone (Am J Surg Pathol 2002;26:64)
  • Hemorrhagic cystic spaces with fibrous septa
Gross images

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Microscopic (histologic) description
  • Cystic spaces filled with blood
  • Fibrous septa composed of fibroblasts, osteoclast-type giant cells, woven bone
Microscopic (histologic) images

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Molecular / cytogenetics description
  • 46,XY, t(17;17)(p13;q12), similar to intraosseous aneurysmal bone cyst
  • Also t(16;17)(q22;p13)
  • USP6 locus rearrangement on chromosome 17p13 (J Bone Joint Surg Am 2011;93:e45)
Differential diagnosis
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