Soft tissue
So called fibrohistiocytic
Fibrohistiocytic tumors-general
Author: Brendan C. Dickson, M.D., M.Sc.
Resident / Fellow Advisory Board: Josephine K. Dermawan, M.D., Ph.D.
Deputy Editor-in-Chief: Borislav A. Alexiev, M.D.
Last author update: 21 November 2022
Last staff update: 21 November 2022
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PubMed Search: Fibrohistiocytic soft tissue tumors
Table of Contents
Definition / generalCite this page: Dickson BC. Fibrohistiocytic tumors-general. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuefibrohistiocyticgeneral.html. Accessed May 29th, 2023.
Definition / general
- Due to controversy over the precise lineage of these tumors, they are termed fibrohistiocytic tumors (Fletcher: WHO Classification of Tumours of Soft Tissue and Bone, 4th Edition, 2013)
- Tumors previously called malignant fibrous histiocytoma (MFH) are now called undifferentiated or unclassified sarcoma; based on cell morphology, they are subclassified as undifferentiated pleomorphic sarcoma, undifferentiated spindle cell sarcoma, undifferentiated epithelioid cell sarcoma and undifferentiated round cell sarcoma
- Tumors currently within this category include tenosynovial giant cell tumor, deep fibrous histiocytoma, plexiform fibrohistiocytic tumor and giant cell tumor of soft tissue (WHO Classification of Tumours Editorial Board: Soft Tissue and Bone Tumours, 5th Edition, 2020)
