Soft tissue


Histology-fibrous tissue & nerve

Last author update: 1 July 2012
Last staff update: 21 May 2024 (update in progress)

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PubMed Search: Normal histology of soft tissue [title]

Komal Arora, M.D.
Page views in 2024 to date: 1,998
Cite this page: Arora K. Histology-fibrous tissue & nerve. website. Accessed July 14th, 2024.
Definition / general
  • Fibrous tissue consists of fibroblasts and extracellular matrix
  • Extracellular matrix consists of collagen, elastin and ground substance

Fibrous tissue:
  • Loose or dense
  • Dense fibrous tissue includes tendons (connect muscle to bone), ligaments (connect bones or cartilage to each other), aponeuroses (ribbon-like tendinous expansion)

  • Spindled (along collagen fibers) to stellate (star shaped in myxoid areas)
  • Produce various collagens
  • Positive for vimentin, actin

  • Quiescent stage of fibroblasts

  • Modified fibroblasts with multiple possible origins (see diagram below), including transition from fibroblasts during tissue repair (J Invest Dermatol 2007;127:526)
  • Features are intermediate between fibroblasts and smooth muscle cells
  • Composed of axons, Schwann cells, perineurial cells and fibroblasts in epineurium (outer sheath)
  • Perineurium: surrounds each nerve fascicle, is continuous with pia mater of CNS
  • Perineurial cells: derived from fibroblasts; EMA+, S100-
  • Schwann cells: neuroectodermally derived cells that resemble fibroblasts but strongly S100+, intimately related to axons (by EM), have continuous basal lamina that coats the cell facing the endoneurium
Diagrams / tables

Images hosted on other servers:

Myofibroblast progenitors

Microscopic (histologic) images

AFIP images

Myofibroma: interface
of myofibroblastic
tumor with
normal collagen

Images hosted on other servers:

NIH / 3T3 mouse fibroblasts in cell culture

Extracellular matrix compliance
controls development of the
myofibroblast phenotype in
3 dimensional collagen gels

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