Soft tissue

Fibroblastic / myofibroblastic

Gardner-type fibroma

Last author update: 1 July 2012
Last staff update: 14 September 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Gardner type fibroma

Komal Arora, M.D.
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Cite this page: Arora K. Gardner-type fibroma. website. Accessed May 29th, 2023.
Definition / general
  • Benign soft tissue lesion with thick, haphazard collagen and bland fibroblasts that entrap adjacent tissue
  • 90% associated with FAP / Gardner’s syndrome / APC germline mutation
  • Uncommon
  • Affects infants, children and teenagers
  • May be initial diagnostic clue to Gardner’s syndrome and APC mutations (Am J Surg Pathol 2001;25:645)
  • 45% develop desmoid-type fibromatosis
  • Similar histology to nuchal-type fibroma (Pathol Int 2004;54:523, Am J Surg Pathol 2000;24:1563)
  • Superficial or deep soft tissue
  • Various sites
Case reports
Gross description
  • 1 - 10 cm, poorly circumscribed, firm, rubbery, plaque-like, white to tan-pink cut surface with trapped fat in yellow areas
Microscopic (histologic) description
  • Thick, haphazardly arranged collagen bundles, hypocellular bland fibroblasts, small blood vessels, plaque-like growth pattern with infiltration of adjacent structures
Positive stains
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