Soft tissue
Fibroblastic / myofibroblastic
Gardner-type fibroma
Author: Komal Arora, M.D.
Last author update: 1 July 2012
Last staff update: 14 September 2020
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Gardner type fibroma
Table of Contents
Definition / general | Sites | Case reports | Gross description | Microscopic (histologic) description | Positive stains | Negative stains | Additional referencesCite this page: Arora K. Gardner-type fibroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuegardnerfibroma.html. Accessed May 29th, 2023.
Definition / general
- Benign soft tissue lesion with thick, haphazard collagen and bland fibroblasts that entrap adjacent tissue
- 90% associated with FAP / Gardner’s syndrome / APC germline mutation
- Uncommon
- Affects infants, children and teenagers
- May be initial diagnostic clue to Gardner’s syndrome and APC mutations (Am J Surg Pathol 2001;25:645)
- 45% develop desmoid-type fibromatosis
- Similar histology to nuchal-type fibroma (Pathol Int 2004;54:523, Am J Surg Pathol 2000;24:1563)
Sites
- Superficial or deep soft tissue
- Various sites
Case reports
- Post-surgical desmoid tumor in Gardner’s syndrome patient (J Neurooncol 2009;91:107)
Gross description
- 1 - 10 cm, poorly circumscribed, firm, rubbery, plaque-like, white to tan-pink cut surface with trapped fat in yellow areas
Microscopic (histologic) description
- Thick, haphazardly arranged collagen bundles, hypocellular bland fibroblasts, small blood vessels, plaque-like growth pattern with infiltration of adjacent structures
Positive stains
- CD34, cyclin D1, vimentin, nuclear beta-catenin (64%)
Negative stains
Additional references
