Soft tissue

Skeletal muscle


Genital type rhabdomyoma

Last author update: 1 November 2012
Last staff update: 17 December 2021

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PubMed Search: Genital [title] rhabdomyoma

Vijay Shankar, M.D.
Page views in 2021: 897
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Cite this page: Shankar V. Genital type rhabdomyoma. website. Accessed August 14th, 2022.
Definition / general
  • Rare benign tumor with skeletal muscle differentiation in vagina, vulva or cervix, usually in middle aged women and rarely urethra
  • Extracardiac rhabdomyomas are divided into adult, fetal, and genital (below) histologic types
  • Extracardiac tumors are not associated with tuberous sclerosis
  • Rarely occurs in males in paratesticular region or epididymis or in the tunica vaginalis of the testis or prostate
  • Mean age 42 years
Case reports
  • Local excision is curative
Gross description
  • Well circumscribed, solitary, up to 3 cm
  • Resembles polyp
  • Covered by smooth mucosa
Microscopic (histologic) description
  • Submucosal, polypoid, well circumscribed, no capsule
  • Haphazard strap-like or round striated muscle fibers in fibrous stroma with dilated vessels
  • Cells have abundant eosinophilic cytoplasm with glycogen, cross striations, longitudinal myofibrils
  • Nucleus is round, vesicular, central and uniform
  • May have bi- or multinucleated cells
  • No / rare mitotic figures, no cambium layer, no spider cells, no spindle cells or rhabdomyoblasts, no necrosis, no nuclear pleomorphism
Microscopic (histologic) images

AFIP images
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Submucosal proliferation of haphazard skeletal muscle cells with prominent cross striations and fibromyxoid stroma

Images hosted on other servers:
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Uterine cervix rhabdomyoma

Positive stains
Negative stains
Differential diagnosis
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