Soft tissue
Uncertain differentiation
Pleomorphic hyalinizing angiectatic tumor


Topic Completed: 1 August 2012

Minor changes: 21 April 2021

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PubMed Search: Pleomorphic hyalinizing angiectatic tumor [title]

Vijay Shankar, M.D.
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Cite this page: Shankar V. Pleomorphic hyalinizing angiectatic tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuephat.html. Accessed May 16th, 2021.
Definition / general
Terminology
Epidemiology
  • Low grade malignancy of adults (median age 51 years), often in extremities or trunk
  • May be derived from stromal fibroblasts or primitive undifferentiated mesenchyme
Case reports
Treatment
  • Wide local excision, but 20% recur, rarely as sarcoma
Microscopic (histologic) description
  • Unencapsulated with infiltrative margins
  • Atypical spindle cells that contain hemosiderin and resemble MFH-pleomorphic and schwannoma, have intranuclear and cytoplasmic inclusions
  • Also large ectatic spaces with blood and fibrin and perivascular hyalinization
  • Abundant mast cells, occasional fat
  • Hemosiderotic fibrohistiocytic lipomatous lesion / tumor may be precursor lesion (Am J Surg Pathol 2004;28:1417, but see Orthopedics 2010;33:516)
  • No / rare mitotic figures
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Various images

Cytology description
Positive stains
Negative stains
Molecular / cytogenetics description
  • Case report of 2 unbalanced translocations involving chromosomes 1 and 3 and chromosomes 1 and 10, with a karyotype of 45,XX,der(1)t(1;3)(p31;q12),-3,der(10)t(1;10)(p31;q25)[11]/46,XX4 (Hum Pathol 2012;43:121)
Differential diagnosis
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