Soft tissue
Peripheral nerve
Other benign
Schwannoma-ancient


Topic Completed: 1 November 2012

Minor changes: 1 December 2020

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PubMed Search: Ancient schwannoma [title]

Vijay Shankar, M.D.
Page views in 2020: 4,763
Page views in 2021 to date: 2,011
Cite this page: Shankar V. Schwannoma-ancient. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissueschwannomaancient.html. Accessed May 8th, 2021.
Definition / general
  • Degenerative change to tumors, usually large and of long duration, deep within retroperitoneum
  • Cyst formation, calcification, hemorrhage (stromal hemosiderin), hyalinization, histiocytic infiltration, severe nuclear atypia (nuclear hyperchromasia, irregular nuclear shapes)
  • No mitotic figures
Case reports
Gross images

Case #334

Well circumscribed tumor

Cut section with
variegated appearance,
cystic areas, hemorrhage
and calcification

Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Ancient change



Case #334

Encapsulated mass with calcification

Hypercellular and hypocellular areas

Myxoid change

Hyalinized blood vessels

Enlogated cells with cigar shaped nuclei



Hypercellular areas with palisading

Hyalinized blood vessels

Cystic areas

Cystic areas and blood vessels



Areas of ossification

S100



Images hosted on other servers:

Hypopharyngeal tumor

Thigh mass mimicking malignancy

Abdominal wall mass

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