Soft tissue

Fibroblastic / myofibroblastic

Superficial acral fibromyxoma

Last author update: 1 April 2013
Last staff update: 27 April 2023 (update in progress)

Copyright: 2002-2023,, Inc.

PubMed Search: Superficial acral fibromyxoma

Lauren N. Stuart, M.D., M.B.A.
Jerad M. Gardner, M.D.
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Cite this page: Stuart L. Superficial acral fibromyxoma. website. Accessed June 4th, 2023.
Definition / general
  • Name is accurate - superficial tumor of fingers and toes with bland fibromyxoid histology
  • First described in 2001 (Hum Pathol 2001;32:704)
Clinical features
Prognostic factors
  • Local recurrence almost always associated with positive margins
Case reports
Gross description
  • Well circumscribed, non encapsulated gray-white nodule
  • Can be dome shaped, polypoid, verrucous
  • Cut surface firm, gelatinous, solid (Arch Pathol Lab Med 2011;135:1064)
Microscopic (histologic) description
  • Dermal or subcutaneous tumor composed of bland spindle and stellate cells within a myxoid or collagenous stroma with prominent vessels and mast cells
  • Cells are arranged in random, loose storiform and fascicular growth patterns
  • Mild nuclear atypia
  • Occasional multinuclear stromal cells
  • Rare mitotic figures
  • Rarely infiltrates bone (Am J Surg Pathol 2012;36:789)
  • An epidermal collarette may be present (Dermatol Ther 2020;33:e14517)
Microscopic (histologic) images

Images hosted on other servers:

Tumor at tip of big toe

Spindle cells and mast cells in myxoid matrix (fig1)

CD34+ (fig2)

CD99+ (fig3)

H&E, CD10 and nestin

Positive stains
Differential diagnosis
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