Soft tissue

Fibroblastic / myofibroblastic

Superficial acral fibromyxoma

Topic Completed: 1 April 2013

Minor changes: 3 September 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Superficial acral fibromyxoma

Lauren N. Stuart, M.D., M.B.A.
Jerad M. Gardner, M.D.
Page views in 2020: 6,274
Page views in 2021 to date: 7,005
Cite this page: Stuart L. Superficial acral fibromyxoma. website. Accessed October 15th, 2021.
Definition / general
  • Name is accurate - superficial tumor of fingers and toes with bland fibromyxoid histology
  • First described in 2001 (Hum Pathol 2001;32:704)
Clinical features
Prognostic factors
  • Local recurrence almost always associated with positive margins
Case reports
Gross description
  • Well circumscribed, non encapsulated gray-white nodule
  • Can be dome shaped, polypoid, verrucous
  • Cut surface firm, gelatinous, solid (Arch Pathol Lab Med 2011;135:1064)
Microscopic (histologic) description
  • Dermal or subcutaneous tumor composed of bland spindle and stellate cells within a myxoid or collagenous stroma with prominent vessels and mast cells
  • Cells are arranged in random, loose storiform and fascicular growth patterns
  • Mild nuclear atypia
  • Occasional multinuclear stromal cells
  • Rare mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Tumor at tip of big toe

Spindle cells and mast cells in myxoid matrix (fig1)

CD34+ (fig2)

CD99+ (fig3)

H&E, CD10 and nestin

Positive stains
Differential diagnosis
Back to top
Image 01 Image 02