Lymph nodes & spleen, nonlymphoid
Thrombotic thrombocytopenic purpura

Topic Completed: 1 October 2012

Minor changes: 5 July 2020

Copyright: 2003-2019,, Inc.

PubMed Search: Thrombotic thrombocytopenic purpura spleen

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Cite this page: Mansouri J. Thrombotic thrombocytopenic purpura. website. Accessed October 24th, 2020.
Definition / general
  • Often associated with splenomegaly
Case reports
  • Newborn with acute respiratory distress, marked jaundice and whole body purpuric rash (Case of the Week #403)
Microscopic (histologic) description
  • Thrombi in arteries and arterioles without inflammation (90%)
  • Also PAS+, diastase resistant hyaline subendothelial deposits of platelet and platelet related material (100%), secondary germinal centers (67%), periarteriolar concentric fibrosis (58%), hemosiderin laden macrophages (92%), hemophagocytosis (83%), extramedullary hematopoiesis (42%)
  • No blood lakes, no microaneurysms, no infarcts (Am J Surg Pathol 1990;14:223)
Peripheral smear images

Case of the Week #403

Numerous schistocytes and nucleated RBCs with extremely low platelets on peripheral smear

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