Hematogenous neoplasms
Castleman disease

Topic Completed: 1 January 2013

Minor changes: 1 April 2020

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PubMed Search: Castleman disease spleen

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Cite this page: Mansouri J. Castleman disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/spleencastleman.html. Accessed May 29th, 2020.
Definition / general
  • Also called angiofollicular lymph node hyperplasia
  • Usually no prominent splenomegaly
Microscopic (histologic) description
  • Usually plasma cell type with white pulp hyperplasia and prominent plasmacytosis (Am J Surg Pathol 1988;12:176)
  • Also hyaline vascular type with white pulp hyperplasia and numerous atrophic and hyaline vascular germinal centers, only rare plasma cells
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