Lymphoma & related disorders
Splenic hematogenous neoplasms
Chronic myelogenous leukemia

Topic Completed: 1 January 2013

Minor changes: 1 April 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Chronic myelogenous leukemia[TI] spleen

See also: Chronic myeloid neoplasms chapter

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Cite this page: Mansouri J. Chronic myelogenous leukemia. website. Accessed August 6th, 2020.
Gross description
  • Large, dark red, diffuse involvement with no identifiable Malpighian follicles; often infarcts
Microscopic (histologic) description
  • Polymorphous infiltrate of myeloid cells in all stages of differentiation
  • Mainly affects splenic red pulp cords and sinuses, obliterates white pulp
  • Rarely blastic transformation (Richter syndrome)
Differential diagnosis
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