Lymph nodes & spleen, nonlymphoma

Spleen-cysts

Epithelial cyst



Last author update: 1 October 2012
Last staff update: 16 February 2024

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PubMed Search: Epithelial cyst spleen

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Cite this page: Mansouri J. Epithelial cyst. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleenepithelialcysts.html. Accessed June 16th, 2024.
Definition / general
  • Usually children or young adults
  • Solitary or multiple; may be associated with accessory spleen
  • May mimic mucinous cystic neoplasm if in intrapancreatic accessory spleen
  • Called "epithelioid" / "epidermoid" if squamous lining
  • Origin unknown; may derive from metaplasia in mesothelial cysts (Am J Surg Pathol 1988;12:275)
  • Often large and requires splenectomy
Case reports
  • 62 year old man with epidermoid cyst in intrapancreatic accessory spleen (JOP 2011;12:279)
Gross description
  • Glistening inner surface with marked trabeculation
Gross images

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Epithelial cyst Epithelial cyst

Epithelial cyst

Microscopic (histologic) description
  • Lined by squamous, columnar, cuboidal or mesothelial-like epithelium
  • No skin adnexae
  • Rarely mucinous and associated with pseudomyxoma peritonei
Microscopic (histologic) images

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Epithelial cyst Epithelial cyst

Epithelial cyst

Positive stains
Differential diagnosis
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