Lymph nodes & spleen, nonlymphoid
Epithelial cyst

Topic Completed: 1 October 2012

Minor changes: 22 July 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Epithelial cyst[TIAB] spleen

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Cite this page: Mansouri J. Epithelial cyst. website. Accessed August 3rd, 2020.
Definition / general
  • Usually children or young adults
  • Solitary or multiple; may be associated with accessory spleen
  • May mimic mucinous cystic neoplasm if in intrapancreatic accessory spleen
  • Called "epithelioid" / "epidermoid" if squamous lining
  • Origin unknown; may derive from metaplasia in mesothelial cysts (Am J Surg Pathol 1988;12:275)
  • Often large and requires splenectomy
Case reports
  • 62 year old man with epidermoid cyst in intrapancreatic accessory spleen (JOP 2011;12:279)
Gross description
  • Glistening inner surface with marked trabeculation
Microscopic (histologic) description
  • Lined by squamous, columnar, cuboidal or mesothelial-like epithelium
  • No skin adnexae
  • Rarely mucinous and associated with pseudomyxoma peritonei
Microscopic (histologic) images

Images hosted on other servers:

Multiple splenic
cysts with
stratified squamous

Cyst lining is CEA+

Positive stains
Differential diagnosis
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