Lymph nodes & spleen, nonlymphoma

Spleen-infectious / inflammatory disorders

Granulomatous inflammation

Topic Completed: 1 October 2012

Minor changes: 12 May 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Granulomatous inflammation[TI] spleen

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Table of Contents
Definition / general | Treatment
Cite this page: Mansouri J. Granulomatous inflammation. website. Accessed October 25th, 2021.
Definition / general
  • Common in splenectomy specimens
  • Either:
    1. Large active granulomas with epithelioid and Langhans giant cells, with or without central necrosis
    2. Widespread small, sarcoid-like epithelioid granulomas with rare giant cells and no necrosis
    3. Inactive granulomas with fibrosis and calcification
  • Granulomas usually associated with systemic disease involving liver, bone marrow and lymph nodes; also chronic uremia, IgA deficiency, infectious mononucleosis
  • Granulomas may be present in hairy cell leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, although granuloma itself does not mean spleen is involved by tumor (Arch Pathol Lab Med 1977;101:518)
  • Active granulomas: in adults, associated with fever, weight loss, hepatosplenomegaly and hypersplenism
  • Inactive granulomas: associated with histoplasmosis
  • Splenectomy for symptoms of hypersplenism
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