Spleen
Hematogenous neoplasms
Hairy cell leukemia - variant type


Topic Completed: 1 January 2013

Minor changes: 1 April 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Hairy cell leukemia variant spleen

See also: Hairy cell leukemia

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Cite this page: Mansouri J. Hairy cell leukemia - variant type. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/spleenhclvariant.html. Accessed May 27th, 2020.
Definition / general
  • 10% of cases, more aggressive; poor response to interferon
  • Mean age 70 years, often men with massive splenomegaly, marked lymphocytosis without infection, successful marrow aspirates
  • Japanese variant also exists
Case reports
Microscopic (histologic) description
  • Medium / large leukemic cells, some with cytoplasmic projections
  • Large, central nuclei with prominent nucleoli, occasionally with clover leaf-like nuclei
  • "Fried egg" appearance in bone marrow
  • May lack blood lakes
Microscopic (histologic) images

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Various images

Positive stains
Negative stains
Flow cytometry images

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Various images

Differential diagnosis
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