Lymph nodes & spleen, nonlymphoma

Spleen-vascular tumors


Last author update: 1 October 2013
Last staff update: 14 June 2021

Copyright: 2003-2023,, Inc.

PubMed Search: Hemangioendothelioma spleen

Vijay Shankar, M.D.
Page views in 2022: 2,596
Page views in 2023 to date: 1,047
Cite this page: Shankar V. Hemangioendothelioma. website. Accessed May 29th, 2023.
Definition / general
  • Very rare, low grade malignant primary vascular tumor of spleen, with intermediate biologic behavior between hemangioma and angiosarcoma
  • Often young, no gender predilection
Clinical features
  • Vague pain, palpable mass and fatigue
  • Functional hyposplenism, spontaneous or traumatic rupture can occur
  • Rarely mild anemia, indirect hyperbilirubinemia
  • Based on radiological examination and histopathological confirmation
Radiology description
  • Ultrasound: hypoechoic mass distinct from surrounding spleen
  • CT: low attenuation mass
  • MRI: heterogenous solid lesion
Radiology images

Images hosted on other servers:

Large protruding cystic mass

Hypodense lesions

Case reports
  • Splenectomy
Gross description
  • Well separated lesions, solitary or multiple of variable size
Gross images

Images hosted on other servers:

Multicystic lesion

Microscopic (histologic) description
  • More cellular than hemangioma, less atypical than angiosarcoma
  • Epithelioid or spindled
  • Ill defined vascular spaces lined by cells with mild or moderate atypia
  • Low mitotic index
Positive stains
Differential diagnosis
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