Lymphoma & related disorders
Splenic hematogenous neoplasms
Hepatosplenic alpha / beta

Topic Completed: 1 March 2013

Minor changes: 5 July 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Hepatosplenic alpha / beta T cell lymphoma

Page views in 2019: 206
Page views in 2020 to date: 107
Cite this page: Mansouri J. Hepatosplenic alpha / beta. website. Accessed August 3rd, 2020.
Definition / general
  • Rare; < 50 cases reported
  • Similar clinical presentation as hepatosplenic gamma / delta T cell lymphoma; also aggressive
  • 79% female (although some reports indicate male predominance), wider age distribution than gamma / delta (some children, some age 50+ years)
  • Usually no significant nodal involvement
  • Peripheral blood involvement late in disease; may have blastic transformation
Case reports
Microscopic (histologic) description
  • Involves splenic red pulp, hepatic sinusoids and periportal areas, interstitial bone marrow
  • Medium size tumor cells with scant to moderate cytoplasm (occasionally abundant), round / oval nuclei, inconspicuous nucleoli, irregular chromatin with nucleoli
Microscopic (histologic) images

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Various images

Positive stains
Molecular / cytogenetics description
  • T cell receptor rearrangements, some with isochromosome 7q
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