Table of Contents
Definition / general | Case reports | Clinical images | Microscopic (histologic) description | Positive stains | Differential diagnosisCite this page: Mansouri J. Infectious mononucleosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/spleeninfectiousmono.html. Accessed April 16th, 2024.
Definition / general
- May cause spontaneous splenic rupture and death, often 10 - 21 days after disease onset
- Rupture may be due to increased intrasplenic pressure due to congestion and weakening of splenic capsule from infiltration by immunoblasts
Case reports
- 16 year old girl with spontaneous splenic rupture (Int J Surg Case Rep 2012;3:97)
Clinical images
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Grossly enlarged with haematoma
Microscopic (histologic) description
- Expansion of red pulp with immunoblastic proliferation
- Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells, infiltrate subintima of intratrabecular veins, occasionally exhibit hemophagocytosis
Positive stains
Differential diagnosis
- Hodgkin lymphoma
- Leukemia
- Non-Hodgkin lymphoma
