Lymph nodes & spleen, nonlymphoma

Spleen-infectious / inflammatory disorders

Infectious mononucleosis

Last author update: 1 October 2012
Last staff update: 13 October 2023

Copyright: 2003-2023,, Inc.

PubMed Search: Infectious mononucleosis[TI] spleen[TI]

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Cite this page: Mansouri J. Infectious mononucleosis. website. Accessed November 29th, 2023.
Definition / general
  • May cause spontaneous splenic rupture and death, often 10 - 21 days after disease onset
  • Rupture may be due to increased intrasplenic pressure due to congestion and weakening of splenic capsule from infiltration by immunoblasts
Case reports
Clinical images

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Grossly enlarged with haematoma

Microscopic (histologic) description
  • Expansion of red pulp with immunoblastic proliferation
  • Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells, infiltrate subintima of intratrabecular veins, occasionally exhibit hemophagocytosis
Positive stains
  • Immunoblasts are positive for B and T cell markers, EBV by in situ hybridization, variable CD30
Differential diagnosis
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