Lymph nodes & spleen, nonlymphoma
Spleen-infectious / inflammatory disorders
Uncommon infections


Topic Completed: 1 October 2012

Minor changes: 21 December 2020

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PubMed Search: Hantavirus spleen

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Cite this page: Mansouri J. Uncommon infections. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/spleenuncommoninfections.html. Accessed May 15th, 2021.
AIDS
  • Prior to highly active antiretroviral therapy (HAART), typical findings were white pulp depletion, hemosiderin deposition, spindle cell proliferation and perivascular hyalinization; also infectious and malignant infiltrates (Mod Pathol 2002;15:406)
  • Post-HAART findings include less frequent white pulp depletion but similar rates of splenic involvement by atypical mycobacteria and CMV in those with systemic disease
Hantavirus
  • Rare but deadly disease transmitted to humans through aerosolized virus from rodent urine, droppings or saliva
  • Usually causes pulmonary syndrome with acute respiratory distress syndrome
  • Gross description: dense, rubbery and heavy lungs floating within yellow serous fluid within pleural cavity; no specific splenic findings
  • Micro description: generalized capillary dilation and edema, immunoblasts in red pulp and periarteriolar sheaths of spleen, occasional prominent and swollen endothelial cells
Mycobacteria
  • Small, weakly gram positive bacteria that are acid fast (due to mycolic acid in cell wall) and slow growers (3 - 4 weeks to develop a visible colony)
  • Mycobacterium avium complex (MAC) consists of M. avium and M. intracellulare, which cause disseminated disease associated with advanced HIV; cause pulmonary disease and cervical lymphadenitis in immunocompetent individuals
  • Disseminated MAC is most common systemic bacterial infection in HIV+ patients
  • Spleen may show presence of pseudo-Gaucher cells (J Clin Pathol 2005;58:1113)
  • Treatment: clarithromycin or azithromycin plus ethambutol, for life
Parvovirus
  • Causes "fifth" disease in children, a mild illness with a "slapped cheek" facial rash
  • Pregnant women may pass virus to fetus, where it causes marked fetal anemia and hydrops
  • Attacks erythroblasts, affecting those with minimal reserve (sickle cell patients, fetuses)
Typhoid fever
  • Due to Salmonella typhi infection
  • Causes inflammatory destruction of GI tract mucosa
  • Bacteremic phase may cause splenomegaly with destruction of splenic vessels
Case reports
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