Cite this page: Mansouri J. Granulomatosis with polyangiitis (Wegener's). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/spleenwegenersgranulomatosis.html. Accessed May 27th, 2020.
Definition / general
- Splenic involvement rarely diagnosed during life but occurs more frequently than clinically evident (Arch Pathol Lab Med 1996;120:974)
- Name changed in 2011 (J Am Soc Nephrol 2011;22:587)
Microscopic (histologic) description
- Necrotizing granulomatous inflammation, vasculitis with fibrinoid necrosis, vascular thrombosis, diffuse hyalinization of blood vessels, infarction, microcalcifications, hemosiderin deposition