Stains & molecular markers
ARID2
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: ARID2
ARID2
Topic Completed: 1 September 2014
Minor changes: 8 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: ARID2
Table of Contents
Definition / general | Diagrams / tables | Clinical features | Microscopic (histologic) description | Resistance therapies | Molecular / cytogenetics descriptionCite this page: Bradish J. ARID2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsARID2.html. Accessed January 19th, 2021.
Definition / general
- ARID2, AT rich interactive domain containing protein 2, functions as a tumor suppressor gene / protein
- It is located on chromosome 12q
- ARID2 is a subunit of a chromatin remodeling complex
- It functions to facilitate ligand dependent transcriptional activity by nuclear receptors (Genes Dev 2005;19:1662, Oncotarget 2011;2:886)
Diagrams / tables
Images hosted on other servers:
ARID2 associations
Clinical features
- ARID2 is associated with melanoma and hepatocellular carcinoma most commonly but has been described in many other tumors
- No studies have described specific histological findings with ARID2 mutations
Microscopic (histologic) description
- Detection of ARID2 mutations is not routinely performed in melanocytic proliferations
- Inactivation mutations can be detected through whole exome sequencing and microarray
- No mechanisms of resistance have been evaluated
Resistance therapies
- No resistance therapies have been evaluated
Molecular / cytogenetics description
- ARID2 mutations causing disease are loss of function mutations
- Nonsense mutations are predicted to lack the Zn motifs required for DNA binding
- There is some suggestion that UVB may cause some of these mutations leading to melanomagenesis (Cell 2012;150:251)
