Stains & CD markers
Cytokeratin 8 (CK8, K8)


Last author update: 1 October 2013
Last staff update: 25 June 2021

Copyright: 2003-2024, PathologyOutlines.com, Inc.

PubMed Search: CK8[title]

Nat Pernick, M.D.
Page views in 2024 to date: 1,151
Cite this page: Pernick N. Cytokeratin 8 (CK8, K8). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsCK8.html. Accessed April 14th, 2024.
Definition / general
Uses by pathologists
Positive staining - normal
  • Gallbladder
  • Intestine
  • Liver (hepatocytes and bile ductules)
  • Pancreas
  • Prostate (basal cells and secretory cells)
  • Simple type (single layer) epithelium including breast ducts (luminal cells)
Positive staining - not malignant
Positive staining - malignant
Negative staining
Microscopic (histologic) images

Contributed by Leica Microsystems (Biosystems Division)

Colon (normal)
CK8 / 18 (5D3)
with intense cytoplasmic
and membranous staining



Images hosted on other servers:

Hepatocytes (residual)
are CK8+ in embryonal
sarcoma of liver

Liver disease (various)

Prostatic adenocarcinoma-top and benign prostate bottom

Squamous cell carcinoma-oral (fig C/D)

Additional references
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