Stains & molecular markers
DOG1
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: DOG1 [title]
DOG1
Author: Nat Pernick, M.D.
Topic Completed: 1 November 2011
Minor changes: 6 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: DOG1 [title]
Table of Contents
Definition / general | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. DOG1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsDOG1.html. Accessed January 22nd, 2021.
Definition / general
- Discovered On GIST 1
- Chloride channel protein
Interpretation
- Membranous and cytoplasmic staining
Uses by pathologists
- Sensitive and specific marker for GIST (Gut Liver 2011;5:171)
- May be more sensitive and specific for GIST than CD117 / KIT in cell blocks (Cancer Cytopathol 2011;119:202, Am J Clin Pathol 2011;135:448)
- Sensitive for CD117 negative GIST tumor (non-GI tumors are usually DOG1+, Am J Surg Pathol 2011;35:1287, Mod Pathol 2011;24:866)
- Negative staining suggests tumor is not GIST (Cancer Control 2011;18:152)
- Distinguish gastric plexiform fibromyxoma (alpha smooth muscle actin+, KIT-, DOG1-, CD34-, no KIT / PDGFRA mutations) from GIST (opposite, Am J Surg Pathol 2009;33:1624)
- Marker for interstitial cells of Cajal in GI tract
- Differentiate salivary acinic cell carcinoma (consistently positive in an apical membranous pattern, Mod Pathol 2012;25:919), and negative in mimics including secretory carcinoma (Mod Pathol 2015;28:1084)
Microscopic (histologic) images
Images hosted on other servers:
GIST: p16, DOG1 and PDGFRA
GIST and other tumors
Positive staining - normal
- Gastric epithelium, interstitial cells of Cajal, pancreatic centroacinar cells (Hum Pathol 2011;42:817), pancreatic endocrine cells (Appl Immunohistochem Mol Morphol 2009;17:413)
Positive staining - disease
- GIST, pancreatic solid-pseudopapillary neoplasm (Hum Pathol 2011;42:817)
- Often esophageal squamous cell and gastric carcinomas
- Occasionally uterine type retroperitoneal leiomyomas colonized by DOG1+ Cajal cells, peritoneal leiomyomatosis, synovial sarcomas (Am J Surg Pathol 2009;33:1401)
