Stains & CD markers

Editorial Board Member: Christian M. Schürch, M.D., Ph.D.
Deputy Editor-in-Chief: Catherine E. Hagen, M.D.
Nick Baniak, M.D.

Last author update: 2 September 2021
Last staff update: 2 September 2021

Copyright: 2002-2024,, Inc.

PubMed Search: DOG1[title] "last 5 years"[DP]

Nick Baniak, M.D.
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Cite this page: Baniak N. DOG1. website. Accessed June 16th, 2024.
Definition / general
  • Discovered on GIST 1
  • Primarily used in the diagnosis of gastrointestinal stromal tumor (GIST)
Essential features
  • Monoclonal (SP31, K9, DOG1.1) and polyclonal antibodies (Cancer Control 2015;22:498)
  • Most sensitive and specific marker for GIST
  • Membranous and cytoplasmic
Uses by pathologists
Microscopic (histologic) images

Contributed by Nick Baniak, M.D.
H&E resection


H&E biopsy


Diffuse staining Diffuse staining

Diffuse staining

Diffuse staining Diffuse staining

Diffuse staining

Positive staining - normal
Positive staining - disease
Negative staining
Sample pathology report
  • Stomach, biopsy:
    • Gastrointestinal stromal tumor (see comment)
    • Comment: Immunohistochemistry performed at X institution reveals the following immunoprofile (controls stained appropriately): positive - DOG1.
Board review style question #1

DOG1 may be a particularly important biomarker for GISTs with which mutation, due to the more frequent finding of CD117 and CD34 negativity?

  1. KIT
  2. NF
  3. PDGFRα
  4. SDH
Board review style answer #1

Comment Here

Reference: DOG1
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