Stains & molecular markers
DOG1


Topic Completed: 1 November 2011

Minor changes: 6 May 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: DOG1 [title]

Nat Pernick, M.D.
Page views in 2020: 11,190
Page views in 2021 to date: 4,599
Cite this page: Pernick N. DOG1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsDOG1.html. Accessed May 12th, 2021.
Definition / general
  • Discovered On GIST 1
  • Chloride channel protein
Interpretation
  • Membranous and cytoplasmic staining
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
Missing Image Missing Image

GIST: p16, DOG1 and PDGFRA

Missing Image Missing Image Missing Image

GIST and other tumors

Positive staining - normal
Positive staining - disease
  • GIST, pancreatic solid-pseudopapillary neoplasm (Hum Pathol 2011;42:817)
  • Often esophageal squamous cell and gastric carcinomas
    • Occasionally uterine type retroperitoneal leiomyomas colonized by DOG1+ Cajal cells, peritoneal leiomyomatosis, synovial sarcomas (Am J Surg Pathol 2009;33:1401)
Back to top
Image 01 Image 02