Stains & CD markers
ERG

Editor-in-Chief: Debra L. Zynger, M.D.

Topic Completed: 24 April 2019

Minor changes: 18 August 2021

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PubMed Search: ERG [title] stain

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Cite this page: Michal M. ERG. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsERG.html. Accessed October 24th, 2021.
Definition / general
  • Transcriptional regulator ERG is a protein encoded by ERG (ETS family transcription factor ERG), which is located at 21q22
  • Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity
  • Highly sensitive immunohistochemical marker for vascular differentiation and cartilaginous differentiation (anti-N terminus antibody), expressed also in half of prostatic adenocarcinomas and in Ewing sarcomas with ERG rearrangement
Essential features
  • ETS family transcription factor ERG has nuclear staining
  • Highly sensitive and quite specific immunohistochemical marker for vascular differentiation, including benign and malignant vascular tumors
  • Anti-N terminus ERG monoclonal antibody is a useful marker for certain chondrogenic tumors
  • Also expressed in tumors harboring ERG rearrangements: 50% of prostatic adenocarcinomas and 5% of Ewing sarcomas
Terminology
  • V-ets erythroblastosis virus E26 oncogene homolog
  • ERG3
  • p55
  • Transcriptional regulator ERG (transforming protein ERG)
Interpretation
  • Nuclear staining
Uses by pathologists
Diagrams / tables

Images hosted on other servers:
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ERG rearrangement

Clinical features
Microscopic (histologic) images

Contributed by Michael Michal, M.D., Ph.D.

Epithelioid angiosarcoma

Epithelioid hemangioendothelioma

Epithelioid hemangioma

Metastatic prostate
adenocarcinoma with
TMPRSS2-ERG
fusion

EWSR1-SMAD3 rearranged fibroblastic tumor



Contributed by Brendan C. Dickson, M.D., MSc

Ewing sarcoma


Contributed by Debra Zynger, M.D.

Lymphovascular invasion

Positive staining - normal
  • Both blood vessel and lymphatic endothelial cells
  • Subpopulation of immature myeloid cells in an adult bone marrow
  • Early embryonic subepidermal and paraspinal mesenchyme and periphery of cartilage (Am J Surg Pathol 2011;35:432)
Positive staining - disease
Negative staining
  • Nuclear expression is absent in the vast majority of nonprostatic carcinomas and other mesenchymal, neuroectodermal and hematopoietic tumors (Am J Surg Pathol 2011;35:432)
Molecular / cytogenetics images

Images hosted on other servers:
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Prostatic adenocarcinoma (FISH)

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Prostatic small cell carcinoma (FISH)

Board review style question #1
Which of the following neoplasms will most likely be ERG negative?

  1. Angiosarcoma
  2. Chondrosarcoma
  3. Colorectal adenocarcinoma
  4. Ewing sarcoma with EWSR1-ERG fusion
  5. Prostate adenocarcinoma with TMPRSS2-ERG fusion
Board review style answer #1
C. Colorectal adenocarcinoma

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Reference: ERG
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