Stains & molecular markers

Topic Completed: 1 July 2009

Minor changes: 16 December 2020

Copyright: 2002-2021,, Inc.

PubMed Search: HE4 stain

Nat Pernick, M.D.
Page views in 2020: 149
Page views in 2021 to date: 9
Cite this page: Hamilton K, Pernick N. HE4. website. Accessed January 17th, 2021.
Definition / general
  • Antibody against Human Epididymis protein 4, a protease inhibitor
  • Also called WAP5 and WFDC2 (WAP four-disulfide core domain 2)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Respiratory tract and salivary glands

Cystic fibrosis of lung

Major and minor glands (Fig B, E)

Pulmonary neoplasms

Ovarian carcinoma - various subtypes

Positive staining - normal
  • Breast (female)
  • Colonic mucosa
  • Epididymis (Biol Reprod 1991;45:350) and vas deferens
  • Female genital tract (endocervix, endometrium, fallopian tube, ovary)
  • Renal tubules
  • Respiratory epithelium
  • Salivary glands
Positive staining - disease
Negative staining
  • Most nonovarian carcinomas
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