Stains & CD markers
HGAL
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: HGAL [title]
HGAL
Author: Nat Pernick, M.D.
Last author update: 1 November 2011
Last staff update: 2 July 2021
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: HGAL [title]
Table of Contents
Definition / general | Pathophysiology | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. HGAL. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsHGAL.html. Accessed September 22nd, 2023.
Definition / general
- Human germinal center-associated lymphoma; also called germinal center B-cell expressed transcript 2
- NOT human-galectin
Pathophysiology
- Inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade (Blood 2010;116:5217)
- Also interacts with actin and myosin proteins and reduces the maximum velocity of myosin head / actin movement (FEBS J 2011;278:1922)
Uses by pathologists
- More sensitive for follicular lymphoma than bcl6 and CD10 (Diagn Pathol 2011;6:97), and particularly helpful in detecting its interfollicular and diffuse components (Am J Surg Pathol 2010;34:1266)
- Favorable marker in diffuse large B cell lymphoma (Blood 2003;101:433) and classical Hodgkin lymphoma (Leuk Lymphoma 2009;50:1830, Blood 2007;109:298)
- Help classify cutaneous large B-cell lymphomas (Mod Pathol 2008;21:653)
Microscopic (histologic) images
Images hosted on other servers:
Follicular neoplasms
Normal tonsil
NMZL
Classical Hodgkin lymphoma
Positive staining - normal
- Germinal center lymphocytes
Positive staining - disease
- Germinal center derived lymphomas, including follicular center cell lymphoma
