Stains & molecular markers
HGAL


Topic Completed: 1 November 2011

Minor changes: 18 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: HGAL [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. HGAL. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsHGAL.html. Accessed September 20th, 2020.
Definition / general
  • Human germinal center-associated lymphoma; also called germinal center B-cell expressed transcript 2
  • NOT human-galectin
Pathophysiology
  • Inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade (Blood 2010;116:5217)
  • Also interacts with actin and myosin proteins and reduces the maximum velocity of myosin head / actin movement (FEBS J 2011;278:1922)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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Normal tonsil

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Follicular neoplasms


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NMZL

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Classical Hodgkin lymphoma

Positive staining - normal
  • Germinal center lymphocytes
Positive staining - disease
  • Germinal center derived lymphomas, including follicular center cell lymphoma
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