Stains & CD markers
IFITM1

Editorial Board Member: Christian M. Schürch, M.D., Ph.D.
Deputy Editor-in-Chief: Jennifer A. Bennett, M.D.
Aurelia Busca, M.D., Ph.D.

Last author update: 10 March 2022
Last staff update: 10 March 2022

Copyright: 2022, PathologyOutlines.com, Inc.

PubMed Search: IFITM1 [TI]

Aurelia Busca, M.D., Ph.D.
Page views in 2022: 487
Page views in 2023 to date: 56
Cite this page: Busca A. IFITM1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsIFITM1.html. Accessed January 28th, 2023.
Definition / general
  • Part of the IFITM family (interferon induced transmembrane protein); involved in interferon mediated, antiviral immune response and tumor growth and proliferation
  • Useful as a marker of endometrial stromal differentiation
Essential features
  • Part of the IFITM family (interferon induced transmembrane protein, IFITM1, IFITM2, IFITM3)
  • Downstream molecule of the Wnt / beta catenin signaling pathway in pregnancy related uterine growth and uterine development
  • Marker of endometrial stroma and endometrial stromal differentiation in spindle cell lesions
  • Increased IFITM1 expression correlates with increased TNM stage and poor prognosis in gallbladder, colorectal and breast carcinomas
Terminology
  • CD225
Pathophysiology
Interpretation
  • Cytoplasmic staining
Uses by pathologists
Prognostic factors
Microscopic (histologic) images

Contributed by Aurelia Busca, M.D., Ph.D.
Myometrial invasion Myometrial invasion

Myometrial invasion

Myometrial invasion, IFITM1 Myometrial invasion, IFITM1

Myometrial invasion, IFITM1

Adenomyosis

Adenomyosis

Adenomyosis, IFITM1

Adenomyosis, IFITM1

Positive staining - normal
Positive staining - disease
Negative staining
Sample pathology report
  • Endometrium, curettings:
    • Spindle cell lesion, most consistent with endometrial stromal neoplasm (see comment)
    • Comment: Sections show a spindle cell lesion with bland nuclear features, resembling endometrial stroma and presence of small arterioles. By immunohistochemistry, the lesional cells are positive for CD10 and IFITM1 (endometrial stromal markers) and negative for desmin and caldesmon (smooth muscle markers). The findings are most consistent with a low grade endometrial stromal neoplasm. Definite classification (endometrial stromal nodule versus low grade endometrial stromal sarcoma) requires a resection specimen.
Board review style question #1

Which of the following statements is true about the endometrial carcinoma and IFITM1 immunostain illustrated in the photos shown above?

  1. IFITM1 highlights the endometrial stroma
  2. IFITM1 highlights the myometrium
  3. Pattern of staining supports the fact that the tumor is not invasive into myometrium
  4. Tumor is IFITM1 positive
Board review style answer #1
A. IFITM1 highlights the endometrial stroma

Comment Here

Reference: IFITM1
Board review style question #2
Which of these lesions is typically IFITM1 positive?

  1. Cellular leiomyoma
  2. Conventional leiomyoma
  3. High grade endometrial stromal sarcoma
  4. Low grade endometrial stromal sarcoma
Board review style answer #2
D. Low grade endometrial stromal sarcoma

Comment Here

Reference: IFITM1
Back to top
Image 01 Image 02