Stains & CD markers
OCT2


Last author update: 19 October 2022
Last staff update: 31 October 2022

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PubMed Search: OCT2 pathology

Sawsan Ismail, M.D.
John Yahya I. Elshimali, M.D.
Page views in 2022: 3,428
Page views in 2023 to date: 423
Cite this page: Ismail S, Elshimali JYI. OCT2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsOCT2.html. Accessed February 4th, 2023.
Definition / general
Essential features
  • B cell restricted transcription factor
  • Encoded by the gene POU2F2
  • Binds to an octamer DNA motif 5'-ATGCAAAT-3'
  • Essential for B cell maturation and immunoglobulin production
Terminology
  • Octamer binding protein 2 (OCT2)
Pathophysiology
Diagrams / tables

Images hosted on other servers:

Electromobility shift and supershift analysis (OCT2)

Clinical features
Interpretation
  • OCT2 immunostaining demonstrates nuclear expression
Uses by pathologists
Prognostic factors
Microscopic (histologic) description
  • Positive cells should demonstrate a moderate to strong nuclear staining pattern
Microscopic (histologic) images

Contributed by Sawsan Ismail, M.D. and John Yahya I. Elshimali, M.D.
Diffuse large B cell lymphoma Diffuse large B cell lymphoma Diffuse large B cell lymphoma

Diffuse large B cell lymphoma

Marginal zone lymphoma Marginal zone lymphoma

Marginal zone lymphoma


Lymphoblastic lymphoma Lymphoblastic lymphoma

Lymphoblastic lymphoma

Positive staining - normal
Positive staining - disease
Negative staining
Molecular / cytogenetics description
Molecular / cytogenetics images

Contributed by John Yahya I. Elshimali, M.D.
Structure of OCT2 transcription factor

Structure of OCT2 transcription factor

Sample pathology report
  • Axillary lymph node, excisional biopsy:
    • Nodular lymphocyte predominant Hodgkin lymphoma (see comment)
    • Comment: The biopsy shows total replacement of the nodal architecture by expansive, vague nodules of small lymphocytes with sparse, relatively large tumor cells (LP cells) with multilobulated or round nucleus, a thin nuclear membrane, finely granular chromatin and variable small nucleoli (popcorn cells); the background shows numerous small B lymphocytes, epithelioid histiocytes and CD21+ follicular dendritic cells. The LP cells are immunoreactive for CD45 (LCA), CD20, CD19, BCL6, OCT2 (clone EP115), BOB.1 and PU.1 and are negative for CD3, CD15 and CD30. The morphologic and immunophenotypic findings are in support of the diagnosis.
Board review style question #1
Which of the following statements regarding OCT2 is true?

  1. Decreased expression is associated with poor prognosis in multiple myeloma
  2. OCT2 demonstrates positive nuclear expression in nodular lymphocyte predominant Hodgkin lymphoma
  3. OCT2 is used in the differential diagnosis of breast cancer
  4. OCT2.2 is the major isoform and is encoded by variant 3
Board review style answer #1
B. OCT2 demonstrates positive nuclear expression in nodular lymphocyte predominant Hodgkin lymphoma. Increased expression is associated with poor prognosis in multiple myeloma. OCT2.1 is the major isoform and is encoded by variant 2. OCT2 is used in the differential diagnosis of Hodgkin lymphomas.

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Reference: OCT2
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