Stains & molecular markers
A beta 42

Topic Completed: 1 July 2015

Minor changes: 15 September 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Abeta42[title]

Nat Pernick, M.D.
Page views in 2019: 191
Page views in 2020 to date: 122
Cite this page: Pernick N. A beta 42. website. Accessed September 20th, 2020.
Definition / general
  • Aβ42 is generated by sequential processing of β-amyloid precursor protein (APP) by beta and gamma secretase, which likely has a causative role in Alzheimer's disease (AD)
  • Aβ42 is main constituent of amyloid plaque in brains of patients with Alzheimer disease; has 2 common isoforms: Aβ40 is more common, Aβ42 is more amyloidogenic and may lead to formation of plaques (Alzheimers Res Ther 2012;4:9)
  • Production of Aβ42 is enhanced by familial AD mutations in presenilin 1 (PS1) and PS2, as well as by some familial AD mutations in APP (J Biol Chem 2011;286:15240)
Clinical features
Diagrams / tables

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Apolipoprotein E / Aβ interaction pathways
and therapeutic approaches

Microscopic (histologic) images

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Brain tissue of Alzheimer's disease patient

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