Stains & molecular markers

Topic Completed: 1 July 2015

Minor changes: 11 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: ABL[title]

Nat Pernick, M.D.
Page views in 2020: 67
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Cite this page: Pernick N. ABL. website. Accessed January 17th, 2021.
Definition / general
  • Also called c-abl
  • Gene at 9q34.1, named after ABelson murine Leukemia virus
  • Abelson family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration and invasion (Nat Rev Cancer 2013;13:559)
  • Dysregulated tyrosine kinase activates a network of signals that contributes to cytokine independent growth, resistance to apoptosis and genetic instability (Cancer Control 2009;16:100)
  • Also regulates BMP2 induced osteogenesis (J Biol Chem 2013;288:24503)
Clinical features
Diagrams / tables

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Microscopic (histologic) images

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Liver: Hepatocellular carcinoma

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