Stains
Actin - muscle specific


Topic Completed: 1 September 2013

Revised: 4 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Muscle specific actin[title]

Nat Pernick, M.D.
Page views in 2018: 3,956
Page views in 2019 to date: 4,028
Cite this page: Pernick N. Actin - muscle specific. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsactinmusclespecific.html. Accessed November 19th, 2019.
Definition / general
  • Discovered in 1987 (Am J Pathol 1987;126:51); also called HHF35, MSA
  • Recognizes all alpha actins (skeletal, smooth, cardiac) and gamma smooth muscle actin; but not beta cytoplasmic or gamma cytoplasmic actin (the latter is also called non-muscle actin)
  • Recognizes actin expressed in all cells with muscle differentiation (cardiac, smooth and skeletal muscle), myoepithelial cells, myofibroblasts, pericytes and myogenic tumors (Am J Clin Pathol 1991;96:32)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Endometriosis


Myofibroblastoma: breast (fig d)

Myofibroblastoma: lymph node

Prostate: normal smooth muscle stroma


Rhabdomyo-sarcoma: CNS, embryonal (fig 4)

Rhabdomyo-sarcoma: oral cavity

Glomus tumor

Positive staining - normal
  • Cardiac muscle, decidua, myoepithelial cells (although calponin and vimentin may be better, Braz Dent J 2007;18:192), myofibroblasts, pericytes, skeletal muscle, smooth muscle and vascular smooth muscle
Positive staining - disease
Negative staining
Back to top