Stains & molecular markers
Cytokeratin AE1
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: AE1[title]
Cytokeratin AE1
Author: Nat Pernick, M.D.
Topic Completed: 1 October 2013
Minor changes: 15 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: AE1[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative staining | Microscopic (histologic) images | Additional referencesCite this page: Pernick N. Cytokeratin AE1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsae1.html. Accessed April 14th, 2021.
Definition / general
- Usually used in a cytokeratin cocktail with AE3 (see AE1/AE3)
- Detects high molecular weight CK10, CK14, CK15 and CK16 and low molecular weight CK19; these are acidic (type I) cytokeratins
Uses by pathologists
- Highlight bile ducts in liver transplant rejection, particularly if inflammation present (J Clin Pathol 1994;47:303)
Positive staining - normal
- Most epithelium; including bile ducts, bronchial gland secretory cells (Histol Histopathol 2005;20:865)
Positive staining - disease
- Most carcinomas, including biliary tumors (benign or malignant, Am J Surg Pathol 1988;12:187)
- Mesothelioma (Am J Clin Pathol 1987;88:610)
Negative staining
- Adrenocortical carcinoma
- Basal cell carcinoma
- Hepatocytes
- Hepatocellular carcinoma (Am J Clin Pathol 1985;84:697)
Microscopic (histologic) images
Images hosted on other servers:
Liver-bile ducts in severe
acute rejection with dense
lymphoid infiltrate: H&E
(top), AE1 (bottom)
Liver-bile ducts in chronic rejection with dense lymphoid infiltrate: H&E (top), AE1 (bottom)
Additional references
