Stains & molecular markers
Cytokeratin AE1


Topic Completed: 1 October 2013

Minor changes: 15 December 2020

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PubMed Search: AE1[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Cytokeratin AE1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsae1.html. Accessed April 14th, 2021.
Definition / general
  • Usually used in a cytokeratin cocktail with AE3 (see AE1/AE3)
  • Detects high molecular weight CK10, CK14, CK15 and CK16 and low molecular weight CK19; these are acidic (type I) cytokeratins
Uses by pathologists
Positive staining - normal
Positive staining - disease
Negative staining
Microscopic (histologic) images

Images hosted on other servers:

Liver-bile ducts in severe
acute rejection with dense
lymphoid infiltrate: H&E
(top), AE1 (bottom)

Liver-bile ducts in chronic rejection with dense lymphoid infiltrate: H&E (top), AE1 (bottom)

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Image 01 Image 02