Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative staining | Microscopic (histologic) images | Additional referencesCite this page: Pernick N. Cytokeratin AE1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsae1.html. Accessed January 20th, 2021.
Definition / general
- Usually used in a cytokeratin cocktail with AE3 (see AE1/AE3)
- Detects high molecular weight CK10, CK14, CK15 and CK16 and low molecular weight CK19; these are acidic (type I) cytokeratins
Uses by pathologists
- Highlight bile ducts in liver transplant rejection, particularly if inflammation present (J Clin Pathol 1994;47:303)
Positive staining - normal
- Most epithelium; including bile ducts, bronchial gland secretory cells (Histol Histopathol 2005;20:865)
Positive staining - disease
- Most carcinomas, including biliary tumors (benign or malignant, Am J Surg Pathol 1988;12:187)
- Mesothelioma (Am J Clin Pathol 1987;88:610)
Negative staining
- Adrenocortical carcinoma
- Basal cell carcinoma
- Hepatocytes
- Hepatocellular carcinoma (Am J Clin Pathol 1985;84:697)
Microscopic (histologic) images
Additional references