Stains & CD markers
Albumin


Topic Completed: 1 November 2013

Minor changes: 23 June 2021

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PubMed Search: Albumin[TI] free full text[SB] pathology stain

Nat Pernick, M.D.
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Cite this page: Pernick N. Albumin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsalbumin.html. Accessed October 24th, 2021.
Definition / general
  • Most common serum protein
    • 65K protein produced by ALB gene on #4, by liver (Wikipedia)
    • 50% of total plasma protein content; usual serum concentration of 40 g/L
    • Binds to water, bilirubin, calcium, fatty acids, hormones (acts as carrier protein), potassium, sodium, and various drugs
    • Main function of serum albumin is to regulate blood colloidal osmotic pressure
    • Bovine serum albumin (BSA): plasma protein from cows that maintains osmotic pressure in blood plasma for proper distribution of body fluids between intravascular compartments and body tissues
  • Rarely used as IHC marker for liver
Clinical features
Microscopic (histologic) images

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Left: normal liver; right: negative control

Liver and hepatocellular carcinoma

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