Stains
AML1
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: AML1[title]
AML1
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2015
Minor changes: 27 August 2020
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: AML1[title]
Table of Contents
Definition / generalCite this page: Pernick N. AML1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsaml1.html. Accessed September 28th, 2020.
Definition / general
- Gene at 21q22 is DNA binding component of AML1/CBF beta transcription factor complex, most frequent target of translocations in AML via t(8;21) [AML1-ETO]; t(12;21); t(3;21) [AML1-EVI1]
- Fusion products (below) suppress normal AML1 mediated transactivating activity
- Normal AML1 required to establish fetal liver-derived definitive hematopoiesis (stem cells to definitive hematopoietic elements)
