Stains & molecular markers

Topic Completed: 1 January 2014

Minor changes: 11 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: stainsamy1a

Nat Pernick, M.D.
Page views in 2020: 140
Page views in 2021 to date: 9
Cite this page: Pernick N. AMY1A. website. Accessed January 22nd, 2021.
Definition / general
  • Also known as amylase alpha 1A
  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, the first step in digestion of dietary starch and glycogen
  • Humans have cluster of several amylase genes expressed at high levels in salivary gland or pancreas (NCBI Gene)
Clinical features
  • AMY1 genes show extensive copy number variation, which is directly proportional to salivary α-amylase content in saliva (J Nutrigenet Nutrigenomics 2012;5:117)
  • Gene is deleted in chromophobe renal cell carcinoma but not oncocytoma
Uses by pathologists
  • Differentiate oncocytoma (AMY1A+) from chromophobe renal cell carcinoma (both classic and eosinophilic variants are negative, Am J Surg Pathol 2013;37:1824)
Positive staining - disease
  • Oncocytoma
Negative staining
  • Renal carcinomas: chromophone, clear cell, papillary
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