AP2 beta / AP2B1

Topic Completed: 1 December 2014

Minor changes: 15 December 2019

Copyright: 2003-2019,, Inc.

PubMed Search: AP2 beta

Nat Pernick, M.D.
Page views in 2019: 65
Page views in 2020 to date: 13
Cite this page: AP2 beta. website. Accessed June 7th, 2020.
Definition / general
  • Member of AP2 transcription factor family, which consists of five different yet closely related 50-kDa isoforms
  • Also called adapter protein 2 beta, TFAP2b (transcription factor AP 2 beta), Activating enhancer-binding protein-2β
  • Regulates expression of many downstream genes, orchestrating a variety of cell processes, particularly cell induction, differentiation, survival, and proliferation and apoptosis within various developmental contexts (Mol Cancer 2014;13:89, Ann Thorac Surg 2011;92:1044)
  • Assembly protein associated with clathrin-coated vesicles, involved in endocytosis and Golgi processing (Genomics 1995;30:94)
  • Involved in monoaminergic transmission, likely due to a regulatory effect on monoamine oxidase type A and serotonin transporter (Brain Res 2009;1305 Suppl:S20)
Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Non-small cell lung cancer

Lung cancer cells and tumor tissues

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