Stains
APC


Topic Completed: 1 June 2005

Revised: 15 December 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: APC[title]

Nat Pernick, M.D.
Page views in 2019: 129
Page views in 2020 to date: 3
Table of Contents
Definition / general
Cite this page: Pernick N. APC. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsapc.html. Accessed January 17th, 2020.
Definition / general
  • Adenomatous polyposis coli gene on 5q21, tumor suppressor gene, autosomal dominant
  • Important for familial adenomatous polyposis and Gardner syndromes
  • Binds to (a) microtubule bundles and promotes cell migration and adhesion, (b) beta-catenin (cytoskeletal protein) in a cellular adhesion complex including E-cadherin, part of Wnt signaling pathway
  • Beta-catenin is also bound to a T cell factor-lymphoid enhancer factor (Tcf-Lef), which activates other genes, stimulates cell proliferation and inhibits apoptosis
  • APC accelerates the proteasome-mediated degradation of beta-catenin, which reduces its role as a transactivating factor for the Tcf-Lef pathway
  • Mutations in APC produce elevated levels of Tcf4-beta-catenin, which stimulates a transcriptional response that initiates polyp formation and eventually malignant growth
  • APC is considered a gatekeeper gene since it directs activity downstream of different pathways
  • Colon: mutations play critical role in tumorigenesis (mutations in APC or beta-catenin present in 90% of colon cancers)
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