Stains
ATM
Copyright: 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: Ataxia telangiectasia mutated[title]
ATM
Author: Nat Pernick, M.D.
Topic Completed: 1 July 2013
Minor changes: 4 March 2019
Copyright: 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: Ataxia telangiectasia mutated[title]
Table of Contents
Definition / general | Diagrams / tables | Clinical features | Uses by pathologists | Microscopic (histologic) images | Negative stainingCite this page: Pernick N. ATM. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsatm.html. Accessed June 2nd, 2020.
Definition / general
- Ataxia telangiectasia mutated, gene at 11q21-q22 (Wikipedia)
- ATM is protein kinase that activates response to DNA double-strand breaks (Nat Rev Mol Cell Biol 2013;14:197, Front Genet 2013;4:37)
- Mutations cause suboptimal induction of p53 dependent signaling after exposure to DNA damaging agents, which causes an increase in mitotic recombination
- Also has functions essential to neuronal survival and normal function but unrelated to DNA damage (Mech Ageing Dev 2013;134:434)
Ataxia telangiectasia:
- Rare neurodegenerative disorder due to mutation of protein
- Characterized by early-onset, progressive cerebellar ataxia, oculomotor apraxia, choreoathetosis, conjunctival telangiectasias, immunodeficiency
- Also increased risk of malignancy because cells are particularly radiosensitive; increased risk is due to changes occuring in germline cells and as somatic changes in tumors themselves (Oncogene 2014;33:3351)
Diagrams / tables
ATM controls cellular survival
in response to DNA damage
through multiple pathways
Selected summary of the
ATM signaling network
Clinical features
- CLL: frequently ATM abnormalities (Haematologica 2013;98:1124)
- CML: DNA damage-response pathway may determine susceptibility to blast crisis (DNA Repair (Amst) 2013;12:500)
- Glioma: may represent a source of radioresistance in glioma stem cells (Oncol Rep 2013 Jul 11 [Epub ahead of print])
- Prostate: usually higher levels than normal in prostate carcinoma (Am J Clin Pathol 2004;121:231)
Uses by pathologists
- No uses at this time
Microscopic (histologic) images
Images hosted on other servers:
Prostate: ATM expression
in hyperplastic glands of
transitional zone
Prostate: adenocarcinoma
with low ATM staining
Prostate: adenocarcinoma
with normal ATM expression
Prostate: adenocarcinoma
with high ATM staining.
Negative staining
- Loss of 11q21-q22 (ATM) found in nodal, splenic marginal zone and lymphoplasmacytic lymphoma (Mod Pathol 2012;25:651)
