Stains
Bcl-xL


Topic Completed: 1 August 2015

Minor changes: 4 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Bcl-xL[title]

Nat Pernick, M.D.
Page views in 2019: 45
Page views in 2020 to date: 15
Cite this page: Pernick N. Bcl-xL. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsbclxl.html. Accessed June 2nd, 2020.
Definition / general
  • Longer transcript of Bcl-x
  • Protects cells from apoptosis (i.e. anti-apoptotic marker)
  • Relative amounts of pro- and anti-survival BCL2 family of proteins determine if cell will undergo cell death - if more Bcl-xL is present, pores are non-permeable and the cell survives (Wikipedia)
Diagrams / tables

Signal transduction pathways

Clinical features
Interpretation
  • Cytoplasmic staining; colon carcinoma cells serve as positive control
Uses by pathologists
Positive staining - normal
Videos

Bcl-xL forms pore

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