Topic Completed: 1 October 2013

Minor changes: 27 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: bcr-abl[title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. BCR-ABL. website. Accessed September 20th, 2020.
Definition / general
  • Protein fusion product formed by t(9;22)(q34;q11), called the Philadelphia chromosome
  • Either p210 or p185 hybrid proteins
  • p210 formed by bcr from 5' to b2/b3 of M (major)-bcr joined to second exon of c-abl (between IA and IB); has constitutive tyrosine kinase activity; associated with chronic myelogenous leukemia
  • p185 formed by bcr from 5' to m (minor)-bcr; more potent tyrosine kinase than p210; associated with ALL or AML
  • abl overexpression causes resistance to apoptosis induced by Fas, ceramide or chemotherapy
  • Found in 25% adult ALL, 5% pediatric ALL; 95%+ of patients with CML
  • Poor prognostic factor in pediatric ALL
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