Stains
BMP
Copyright: 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: BMP[title]
BMP
Author: Nat Pernick, M.D.
Topic Completed: 1 October 2013
Minor changes: 4 March 2019
Copyright: 2003-2015, PathologyOutlines.com, Inc.
PubMed Search: BMP[title]
Table of Contents
Definition / generalCite this page: Pernick N. BMP. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsbmp.html. Accessed June 7th, 2020.
Definition / general
- Bone Morphogenetic Proteins
- Members of transforming growth factor-beta (TGF-beta) superfamily (20 types cloned through October 2005)
- Used for intercellular signals including cell growth and differentiation
- Ubiquitous in embryonic development; also involved in apoptosis
- Blocking their activity in chickens leads to duck feet
- Deletion causes lack of mesoderm development, lack of sperm development, eye/kidney deformities, misshapen feet
- Overexpression associated with fibrodysplasia ossificans progressiva, various bone and soft tissue sarcomas
- Colonic adenocarcinoma: BMP5 and BMP6 prominent in cytoplasm of tumor cells, BMP2 and BMP4 strongly expressed in surrounding mesenchymal cells
