Stains
Brachyury


Topic Completed: 1 January 2012

Minor changes: 27 August 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: brachyury

Nat Pernick, M.D.
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Cite this page: Pernick N. Brachyury. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsbrachyury.html. Accessed September 28th, 2020.
Definition / general
  • Transcription factor essential for notochordal cell differentiation, elongation of axis and specification of posterior mesodermal elements (Mod Pathol 2009;22:996)
Pathophysiology
  • Brachyury (T) is founding member of T box (Tbx) family
  • Transcriptional activator expressed throughout the nascent mesoderm, tailbud and notochord
  • Involved in the induction and regional specification of mesoderm
  • Brachyury deficient embryos lack tail and trunk structures and die shortly after gastrulation (PLoS One 2011;6:e28394)
  • In tumor cells, induces epithelial-mesenchymal transition, an important step in progression toward metastasis (J Clin Invest 2010;120:533)
Interpretation
  • Nuclear staining
Uses by pathologists
Positive staining - normal
  • Spermatogonia
Positive staining - disease
Negative staining
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