Stains & molecular markers
Cadherins


Topic Completed: 1 October 2013

Minor changes: 11 December 2020

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PubMed Search: cadherins[title]

Nat Pernick, M.D.
Page views in 2020: 553
Page views in 2021 to date: 32
Table of Contents
Definition / general
Cite this page: Pernick N. Cadherins. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscadherins.html. Accessed January 20th, 2021.
Definition / general
  • See also E-cadherin, N-cadherin
  • Molecules that establish links between adjacent cells by forming zipper like structures at adherens junctions
  • Linked to cytoskeleton via catenins (cadherin to beta catenin, beta catenin to alpha catenin, alpha catenin to actin) to stabilize adherens junction
  • Homophilic interactions (like-like) causes clustering of embryonic cells with others from same tissue
  • Loss of cadherins may be first step in giving cells invasive properties
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