Stains & CD markers
CCR1-CCR9 (CD190-CD199)


Topic Completed: 1 January 2012

Minor changes: 23 June 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: CCR1[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CCR1-CCR9 (CD190-CD199). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsccr1.html. Accessed June 23rd, 2021.
CD190
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CCR1 (CD191)
CCR2 (CD192)
  • Receptor for MCP1, MCP3, MCP4 chemokines; alternative coreceptor with CD4 for HIV1
  • Abbreviation for chemokine C-C motif ligand 2 (CCL2)-chemokine C-C motif receptor 2
  • Also known as CD192, but most publications use CCR2
  • Inflammatory cytokine with 374 amino acids that mediates biologic effects of CCL2, also known as monocyte chemoattractant protein 1 (MCP1); CCL2-CCR2 may be involved in neuroinflammation and chronic pain (J Neuroinflammation 2012;9:136)
  • During chemotaxis, may act as scavenger consuming the chemokine (PLoS One 2012;7:e37208)
  • Clinical features:
  • Uses by pathologists: none
  • Positive staining: neurons, monocytes; controversial if expressed on microglia, or due to infiltrating monocytes
CCR3 (CD193)
CCR4 (CD194)
CCR5 (CD195)
  • Chemokine (C-C motif) receptor 5; also known as CD195
  • Surface receptor and attachment site for HIV and SIV into CD4+ cells, along with CXCR4 (CD184) (Exp Biol Med (Maywood) 2011;236:637)
    • Those with CCR5-Δ32 mutation may have HIV resistance (Wikipedia)
  • Receptor for CD8 chemokines RANTES, MIP 1-alpha, MIP 1-beta, monocyte chemoattractant protein 2 (MCP-2)
  • Also receptor for Staphylococcus aureus leukotoxin ED (Nature 2013;493:51)
  • Uses by pathologists: none
  • Positive staining - normal: T cells, macrophages
CCR6 (CD196)
CCR7 (CD197)
CCR8 (CD198)
CCR9 (CD199)
  • Also known as CDw199, GPR28, CC chemokine receptor 9
  • Chemokine receptor; mediates chemotaxis in response to thymus-expressed chemokine (TECK) selectively expressed in thymus and small intestine
  • Clinical features:
  • Uses by pathologists: none at this time
Diagrams / tables

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CCR2: lamina propria lymphocytes

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CCR5: HIV entry into CD4+ cell via CCR5 co-receptor

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CCR6: immature
dendritic cells
traffic to lung via
CCR6 / CCL20 axis

Microscopic (histologic) images

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CCR2: human glomeruli



CCR3:
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Atherosclerosis

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Eosinophils and airway epithelium


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Lymph node: Hodgkin disease

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Skin: cutaneous T cell lymphoma

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Paraffin embedded malignant melanoma

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Renal cell carcinoma


CCR4:
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Lymph node: normal

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Lymph node and peripheral blood: adult T cell leukemia / lymphoma

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Skin: Sézary Syndrome



CCR6:
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Lung: nonsmall cell lung carcinoma

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Lung: sarcoidosis

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Lymph node: melanoma

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Spleen: memory T cells

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Tonsils: inflamed



CCR7:
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Breast: various carcinomas

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Colorectum: T cells in advanced adenocarcinoma

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Esophagus: squamous cell carcinoma and metastatic lymph node

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Lymphoma T cell

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Skin: melanoma and sentinel lymph node


CCR9:
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Ovary: normal and carcinoma

Virtual slides

CCR9:
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Cerebellum

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Tonsil

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Lymph node

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Pancreas

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Cerebral cortex

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Spleen


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Ovarian stroma cells

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Bone marrow

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Parathyroid

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Prostate

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Pancreatic cancer

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