Stains & molecular markers
CCR3 (CD193)

Topic Completed: 1 October 2012

Minor changes: 9 September 2020

Copyright: 2003-2021, Inc.

PubMed Search: CCR3[title]

Nat Pernick, M.D.
Page views in 2020: 117
Page views in 2021 to date: 10
Cite this page: Pernick N. CCR3. website. Accessed January 16th, 2021.
Definition / general
  • C-C chemokine receptor type 3; also known as CD193
  • G protein-coupled receptor for eotaxins
  • Marker for Th2 cells (type 2 helper T cells, which promote humoral immune system)
  • Constitutively expressed at high levels in eosinophils; primary chemokine receptor responsible for eosinophil recruitment to inflamed tissues (Exp Mol Med 2012;44:268)
Clinical features
Uses by pathologists
Microscopic (histologic) images

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Eosinophils and airway epithelium

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Lymph node: Hodgkin disease

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Skin: cutaneous T cell lymphoma

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Paraffin embedded malignant melanoma

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Renal cell carcinoma

Positive staining - normal
  • Bronchial smooth muscle and epithelium (Clin Exp Allergy 2012;42:1040)
  • Eosinophils, basophils, mast cells
  • Th2 helper cells
  • Epidermal keratinocytes and dermal fibroblasts
Positive staining - disease
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