Stains & molecular markers
CCR5 (CD195)
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CCR5[title]
CCR5 (CD195)
Author: Nat Pernick, M.D.
Topic Completed: 1 April 2013
Minor changes: 14 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CCR5[title]
Table of Contents
Definition / general | Diagrams / tables | Uses by pathologists | Positive staining - normalCite this page: Pernick N. CCR5. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsccr5.html. Accessed January 20th, 2021.
Definition / general
- Chemokine (C-C motif) receptor 5; also known as CD195
- Surface receptor and attachment site for HIV and SIV into CD4+ cells, along with CXCR4 (CD184) (Exp Biol Med (Maywood) 2011;236:637); those with CCR5-Δ32 mutation may have HIV resistance (Wikipedia)
- Receptor for CD8 chemokines RANTES, MIP 1-alpha, MIP 1-beta, monocyte chemoattractant protein 2 (MCP-2)
- Also receptor for Staphylococcus aureus leukotoxin ED (Nature 2013;493:51)
Diagrams / tables
Images hosted on other servers:
HIV entry into CD4+ cell via CCR5 co-receptor
Uses by pathologists
- No uses at this time
Positive staining - normal
- T cells, macrophages
