Stains & molecular markers
CCR5 (CD195)

Topic Completed: 1 April 2013

Minor changes: 14 December 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CCR5[title]

Nat Pernick, M.D.
Page views in 2020: 62
Page views in 2021 to date: 10
Cite this page: Pernick N. CCR5. website. Accessed January 20th, 2021.
Definition / general
  • Chemokine (C-C motif) receptor 5; also known as CD195
  • Surface receptor and attachment site for HIV and SIV into CD4+ cells, along with CXCR4 (CD184) (Exp Biol Med (Maywood) 2011;236:637); those with CCR5-Δ32 mutation may have HIV resistance (Wikipedia)
  • Receptor for CD8 chemokines RANTES, MIP 1-alpha, MIP 1-beta, monocyte chemoattractant protein 2 (MCP-2)
  • Also receptor for Staphylococcus aureus leukotoxin ED (Nature 2013;493:51)
Diagrams / tables

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HIV entry into CD4+ cell via CCR5 co-receptor

Uses by pathologists
  • No uses at this time
Positive staining - normal
  • T cells, macrophages
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