Stains & molecular markers
CCR6 (CD196)
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CCR6
CCR6 (CD196)
Author: Nat Pernick, M.D.
Topic Completed: 1 March 2013
Minor changes: 9 September 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CCR6
Table of Contents
Definition / general | Diagrams / tables | Clinical features | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. CCR6. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsccr6.html. Accessed January 19th, 2021.
Definition / general
- C-C chemokine receptor type 6 gene
- Note: also refers to Clostridium difficile isolate
- Member of G protein-coupled receptor superfamily at 6q27, 374 amino acids (MW 42K Da, Wikipedia)
- Binds only a single ligand, CCL20 / macrophage inflammatory protein 3 alpha / MIP-3 alpha (Exp Cell Res 2011;317:613)
- Important for B lineage maturation, antigen driven B cell differentiation
- Mediates recruitment of T cells to inflamed sites (Arthritis Res Ther 2012;14:R73, J Dermatol 2012;39:838)
- CCL20-CCR6 axis mediates migration of circulating regulatory T cells into tumor microenvironment; may cause tumor progression in colon, liver, lung, prostatic carcinomas (PLoS One 2011;6:e24856, PLoS One 2011;6:e24671)
Diagrams / tables
Images hosted on other servers:
Immature dendritic cells traffic to lung via CCR6 / CCL20 axis
Clinical features
- CCR6 polymorphisms:
- Risk factor for rheumatoid arthritis in Asian females but a protective factor in males (DNA Cell Biol 2012;31:607)
- Associated with chronic GVHD and invasive fungal disease (Biol Blood Marrow Transplant 2011;17:1443)
- May be favorable prognostic factor in lung adenocarcinoma (Tumour Biol 2011;32:197)
- Some statins may help treat psoriasis by inhibiting CCL20/CCR6 interaction (Exp Dermatol 2011;20:855)
- Memory CCR6+ CD4+ T cells are preferential targets for productive HIV1 infection (J Immunol 2011;186:4618)
Uses by pathologists
- No significant clinical uses at this time
Microscopic (histologic) images
Images hosted on other servers:
Lung: nonsmall cell lung carcinoma
Lung: sarcoidosis
Lymph node: melanoma
Spleen: memory T cells
Tonsils: inflamed
Positive staining - normal
- Immature dendritic cells, memory T cells that produce IL17 or IL22 (Th17 or Th22, J Exp Med 2011;208:1875)
- Lymphoid tissue in GI tract
Positive staining - disease
- Gastric carcinoma (Pathol Int 2011;61:645)
- Lymphoma: mantle cell, marginal zone, MALT (Hum Pathol 2002;33:1227)
