Stains & molecular markers
CCR7 (CD197)

Topic Completed: 1 March 2013

Minor changes: 2 September 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CCR7

Nat Pernick, M.D.
Page views in 2020: 181
Page views in 2021 to date: 11
Cite this page: Pernick N. CCR7. website. Accessed January 18th, 2021.
Definition / general
Clinical features
  • Aberrant CCR7 expression in various malignancies has been linked to pro-survival, -invasive, and -metastatic pathways (J Biol Chem 2012;287:3581)
  • CCR7-CCL21 pathway may have role in rheumatoid arthritis angiogenesis (Arthritis Rheum 2012;64:2471)
  • Macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal (Hum Pathol 2009;40:1553)
  • 85 year old man with primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma which transformed from indolent to aggressive phase in association with CCR7+ conversion (Dermatol Online J 2012;18:5)
Uses by pathologists
  • Tumor infiltration by CCR7+ T cells may be favorable prognostic marker in advanced colorectal carcinoma (Clin Cancer Res 2012;18:850)
Microscopic (histologic) images

Images hosted on other servers:
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Breast: various carcinomas

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Colorectum: T cells in advanced adenocarcinoma

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Esophagus: squamous cell carcinoma and metastatic lymph node

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Lymphoma T cell

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Skin: melanoma and sentinel lymph node

Positive staining - normal
Positive staining - disease
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